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Study aim Carnitine s supplementation dose and duration Study design Subjects Outcomes relevant to reproduction Reference Human Studies Single center, prospective study to evaluate whether ALC modulates opiatergic pathway in a group of patients with stress- induced amenorrhea 1 g day ALC orally for 16 weeks 24 patients aged 21 32 years with FHA for the last 6 months were subdivided into 2 groups Group A hypogonadotropic patients, plasma LH levels 3 mIU ml, n 16 Group B normogonadotropic patients, plasma LH levels 3 mIU ml, n 8 ALC administration significantly modulates GnRH and LH secretion in hypothalamic amenorrhea in hypogonadotropic patients ALC probably affects neuroendocrine control of gonadotropin secretion by modulating opiatergic control of GnRH- LH secretion Data support the use of ALC as a therapeutic drug for stress- induced reproductive disorders with low LH levels or hypogonadotropic condition 17 Single center, double blinded, randomized controlled clinical trial to evaluate the effectiveness of LC on improving the ovulation and pregnancy rates as well as adverse metabolic indices in clomiphene- resistant PCOS women 3 g day LC orally from day three until day seven of the cycle 170 clomiphene resistant PCOS women aged less than 35 years were randomly allocated into 2 groups Group A n 85 received 250 mg clomiphene citrate plus LC Group B n 85 received 250 mg clomiphene citrate with placebo The combination of LC and CC significantly improved both the ovulation and the pregnancy rates in clomiphene- resistant PCOS women The number of stimulated follicles reaching 17 mm diameter was significantly higher in Group A as compared to Group B Endometrium at the time of hCG administration was significantly thicker in Group A Serum E2, on the day of hCG administration, was significantly higher in the LC group Pregnancy occurred in 42 85 cycles in Group A 54 <a href=http://buycialis.homes>buy cialis online without a prescription</a> |
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