发表于 2022-12-16 06:36:29
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Independent predictors of increased desmoid risk in one study were said to be 1 germline mutation distal to codon 1399, 2 any family history of gastrointestinal disease, and 3 a strong family history of desmoid tumors buy azithromycin online australia Sensory and motor neuropathies are common and are cumulative; monitor patients for symptoms of peripheral motor and sensory, central and autonomic neuropathy, such as hypoesthesia, hyperesthesia, paresthesia, hyporeflexia, areflexia, neuralgia, jaw pain, decreased vibratory sense, cranial neuropathy, ileus, burning sensation, arthralgia, myalgia, muscle spasm, or weakness, both before and during treatment Orthostatic hypotension may occur; the risk of neurologic toxicity is greater if therapy is administered to patients with preexisting neuromuscular disorders or when other drugs with risk of neurologic toxicity are being given Patients with preexisting severe neuropathy should be treated only after careful risk benefit assessment; interrupt, reduce dose, or discontinue based on severity |
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